Endoscopic scores for inflammatory bowel disease in the era of 'mucosal healing'. old problem, new perspectives

The importance of the endoscopic evaluation in inflammatory bowel disease (IBD) management has been recognized for many years. However, the modalities for reporting endoscopic activity represent an ongoing challenge. To address this, several endoscopic scores have been proposed. Very few have been properly validated, and the use of such tools remains sub-optimal and is mainly restricted to clinical trials. In recent years, a growing emphasis of the concept of 'mucosal healing' as a prognostic marker and therapeutic goal has increased the need for a more accurate definition of endoscopic activity in both ulcerative colitis (UC) and Crohn's Disease (CD). In the present review, the evolution of the challenges related to endoscopic scores in IBD has been analyzed, with particular attention paid to the renewed relevance of endoscopic activity in recent years. Currently, despite the growing relevance of endoscopic activity, evaluating this activity in IBD is still a challenge. The implementation of efficacious endoscopic scores and a better definition of the absence of activity (mucosal healing) are needed.The importance of the endoscopic evaluation in inflammatory bowel disease (IBD) management has been recognized for many years. However, the modalities for reporting endoscopic activity represent an ongoing challenge. To address this, several endoscopic scores have been proposed. Very few have been properly validated, and the use of such tools remains sub-optimal and is mainly restricted to clinical trials. In recent years, a growing emphasis of the concept of 'mucosal healing' as a prognostic marker and therapeutic goal has increased the need for a more accurate definition of endoscopic activity in both ulcerative colitis (UC) and Crohn's Disease (CD). In the present review, the evolution of the challenges related to endoscopic scores in IBD has been analyzed, with particular attention paid to the renewed relevance of endoscopic activity in recent years. Currently, despite the growing relevance of endoscopic activity, evaluating this activity in IBD is still a challenge. The implementation of efficacious endoscopic scores and a better definition of the absence of activity (mucosal healing) are needed

A structural modeling approach for the understanding of initiation and elongation of ALS-linked superoxide dismutase fibrils

Familial amyotrophic lateral sclerosis caused by mutations in copper-zinc superoxide dismutase (SOD1) is characterized by the presence of SOD1-rich inclusions in spinal cords. It has been shown that a reduced intra-subunit disulfide bridge apo-SOD1 can rapidly initiate fibrillation forming an inter-subunits disulfide under mild, physiologically accessible conditions. Once initiated, elongation can proceed via recruitment of either apo or partially metallated disulfide-intact SOD1 and the presence of copper, but not zinc, ions inhibit fibrillation. We propose a structural model, refined through molecular dynamics simulations, that, taking into account these experimental findings, provides a molecular explanation for the initiation and the elongation of SOD1 fibrils in physiological conditions. The model indicates the occurrence of a new dimeric unit, prone to interact one with the other due to the presence of a wide hydrophobic surface and specific electrostatic interactions. The model has dimensions consistent with the SOD1 fibril size observed through electron microscopy and provides a structural basis for the understanding of SOD1 fibrillation

Multi-criteria investigation of a pumped thermal electricity storage (PTES) system with thermal integration and sensible heat storage

In the present paper a multicriteria analysis of a Rankine Pumped Thermal Electricity Storage (PTES) system with low-grade thermal energy integration is performed. The system is composed by an ORC for the discharging phase and a high-temperature heat pump for the charging phase. As previously demonstrated, the low-grade thermal energy can be provided at the heat pump evaporator to boost the PTES performances. As it regards the multi-criteria analysis, a tradeoff is required when electric-to-electric energy ratio ηrt, total exergy exploitation efficiency ψut and energy density ρen, are maximized concurrently. By means of multi-objective optimization, theoretical performances of the system are derived in two different layouts, which are differentiated by the presence, or not, of internal regeneration in charge and discharge subsystems. Results showed that regeneration can be very effective, as it relaxes the tradeoff between the objectives, thus yielding better global performances. Pareto fronts are built and explored to characterize the PTES system. Configurations of interest are proposed, and PTES performances are compared with other storage technologies. Theoretical results showed that, by exploiting thermal energy at temperature lower than 80 °C, ηrt ≈ 0.55 and ρen ≈ 15 kWh/m3 can be concurrently achieved. This can be done at the cost of an inefficient exploitation of the thermal source, as ψut ≈ 0.05. If higher total exergy utilization efficiency is required, storage density can still be maintained high, but ηrt must drop down to 0.4

Rankine carnot batteries with the integration of thermal energy sources: A review

This paper provides an overview of a novel electric energy storage technology. The Thermally Integrated Pumped Thermal Electricity Storage (TI-PTES) stores electric energy as thermal exergy. Compared to standard PTES, TI-PTES takes advantage of both electric and low-temperature heat inputs. Therefore, TI-PTES is a hybrid technology between storage and electric production from low-temperature heat. TI-PTES belongs to a technology group informally referred to as Carnot Batteries (CBs). As the TI-PTES grows in popularity, several configurations have been proposed, with different claimed performances, but no standard has emerged to date. The study provides an overview of the component and operating fluid selection, and it describes the configurations proposed in the literature. Some issues regarding the performance, the ratio between thermal and electrical inputs, and the actual TI-PTES utilisation in realistic scenarios are discussed. As a result, some guidelines are defined. The configurations that utilise high-temperature thermal reservoirs are more extensively studied, due to their superior thermodynamic performance. However, low-temperature TI-PTES may achieve similar performance and have easier access to latent heat storage in the form of water ice. Finally, to achieve satisfactory performance, TI-PTES must absorb a thermal input several times larger than the electric one. This limits TI-PTES to small-scale applications

Choroidal thickness changes measured by enhanced depth imaging optical coherence tomography in third trimester pregnant women

The aim of this article is to underline the effect of pregnancy on the variations of choroidal thickness caused by hormonal and haemodynamic changes

Interpretation of the behaviour of compacted soils using cam-clay extended to unsaturated conditions

This paper is focused on the interpretation of experimental results obtained at the Department of Geotechnical Engineering of the University of Naples Federico II (Italy) to investigate the effects of partial saturation on the volumetric behaviour and the initial shear stiffness of a compacted silt. Tests were performed by using suction-controlled triaxial and resonant column cells. Herein, the compatibility of the results with a Single Stress Model (SSM) is discussed. The SSM allows to highlight that suction can have two effects on the mechanical behaviour of an unsaturated soil: it increases the average volumetric stress acting on the soil skeleton and it has a sort of cementing effect on the soil packing (hardening and cementation)

Natural compounds as therapeutic agents: The case of human topoisomerase ib

Natural products are widely used as source for drugs development. An interesting example is represented by natural drugs developed against human topoisomerase IB, a ubiquitous enzyme involved in many cellular processes where several topological problems occur due the formation of supercoiled DNA. Human topoisomerase IB, involved in the solution of such problems relaxing the DNA cleaving and religating a single DNA strand, represents an important target in anticancer therapy. Several natural compounds inhibiting or poisoning this enzyme are under investigation as possible new drugs. This review summarizes the natural products that target human topoisomerase IB that may be used as the lead compounds to develop new anticancer drugs. Moreover, the natural compounds and their derivatives that are in clinical trial are also commented on

Progressive emergence of double porosity in a silt during compaction

The paper deals with an experimental investigation of water retention properties of a statically compacted unsaturated low plasticity silt. The objective is a deeper understanding of the evolution of an aggregate type fabric at different initial conditions in terms of void ratio and water content. A series of Mercury Intrusion Porosimetry tests (MIP) were performed to provide information about factors influencing fabric changes (effect of mechanical stress due to sample compaction) and fabric-properties relationships (water re-tention curve related to porosimetry). The arrangements of aggregation/particles are also investigated with Environmental Scanning Electron Microscopy (ESEM). The experimental data has been used to calibrate a multimodal water retention model for aggregate which is obtained by linear superposition of sub-curves of the van Genuchten type modified. By comparing the WRC obtained by MIP and under suction controlled conditions it has been found a good agreement between the two method for the drying path